| Trimethyl orthobenzoate Basic information |
| Product Name: | Trimethyl orthobenzoate |
| Synonyms: | (trimethoxymethyl)-benzen;(Trimethoxymethyl)benzene;Methyl orthobenzoate;Orthobenzoic acid, trimethyl ester;Orthobenzoate;Benzene, (trimethoxymethyl)-;à,à,à-trimethoxytoluene;Thrimethyl orthobenzoate |
| CAS: | 707-07-3 |
| MF: | C10H14O3 |
| MW: | 182.22 |
| EINECS: | 211-897-5 |
| Product Categories: | Acetals/Ketals/Ortho Esters;Organic Building Blocks;Oxygen Compounds;bc0001;707-07-3 |
| Mol File: | 707-07-3.mol |
| Trimethyl orthobenzoate Chemical Properties |
| Boiling point | 87-88 °C/7 mmHg (lit.) |
| density | 1.061 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | 180 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in organic solvents. |
| form | Liquid |
| color | Clear colorless |
| Sensitive | Moisture Sensitive |
| BRN | 777623 |
| Stability: | Hygroscopic |
| InChIKey | IECKAVQTURBPON-UHFFFAOYSA-N |
| CAS DataBase Reference | 707-07-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, (trimethoxymethyl)-(707-07-3) |
| EPA Substance Registry System | Benzene, (trimethoxymethyl)- (707-07-3) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-37/39 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29163100 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Trimethyl orthobenzoate Usage And Synthesis |
| Chemical Properties | clear colorless liquid |
| Uses | Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067 |
| General Description | Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide. |
| Trimethyl orthobenzoate Preparation Products And Raw materials |
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