Methyl 1-acetyl-2-oxoindoline-6-carboxylate
Methyl 1-acetyl-2-oxoindoline-6-carboxylate
  • CAS No.:676326-36-6
Other grades of this product :
Methyl 1-acetyl-2-oxoindoline-6-carboxylate Basic information
Product Name:Methyl 1-acetyl-2-oxoindoline-6-carboxylate
Synonyms:Methyl 1-acetyl-2-oxoindoline-6-carboxylate;1-Acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methyl ester;Nintedanib-002;1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;methyl-1-acetyl2-oxoindole-6-carboxylate;Nintedanib impurity 1/Methyl 1-Acetyl-2-oxoindoline-6-carboxylate;1H-Indole-6-carboxylic acid, 1-acetyl-2,3-dihydro-2-oxo-, methyl ester;methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate
CAS:676326-36-6
MF:C12H11NO4
MW:233.22
EINECS:
Product Categories:
Mol File:676326-36-6.mol
Methyl 1-acetyl-2-oxoindoline-6-carboxylate Chemical Properties
Boiling point 489.5±45.0 °C(Predicted)
density 1.330
pka-1.94±0.20(Predicted)
Safety Information
MSDS Information
Methyl 1-acetyl-2-oxoindoline-6-carboxylate Usage And Synthesis
UsesMethyl 1-Acetyl-2-oxoindoline-6-carboxylate is a reagent used in the preparation of Nintedanib (N478290), an angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
Methyl 1-acetyl-2-oxoindoline-6-carboxylate Preparation Products And Raw materials
Raw materialsMethyl 2-oxoindole-6-carboxylate-->Acetic anhydride
Preparation Products(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate

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