| Ethyl indole-2-carboxylate Basic information |
| Product Name: | Ethyl indole-2-carboxylate |
| Synonyms: | INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 2-INDOLECARBOXYLATE;ETHYL 1H-INDOLE-2-CARBOXYLATE;ETHYL INDOLE-2-CARBOXYLATE;2-CARBETHOXYINDOLE;1H-INDOLE-2-CARBOXYLIC ACID, ETHYL ESTER;SPECS AF-966/00545036;Ethyl fluoroindole-2-carboxylate |
| CAS: | 3770-50-1 |
| MF: | C11H11NO2 |
| MW: | 189.21 |
| EINECS: | 223-206-4 |
| Product Categories: | Building Blocks;C11;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Heterocycle-Indole series;Pharmaceutical Intermediates;Esters;Pyrroles & Indoles;Indole;Indoles;Simple Indoles;Pyrroles & Indoles;Heterocyclic Building Blocks;Indole/indoline/oxindole;Indole and Indoline;Indoles and derivatives |
| Mol File: | 3770-50-1.mol |
| Ethyl indole-2-carboxylate Chemical Properties |
| Melting point | 122-125 °C (lit.) |
| Boiling point | 324.47°C (rough estimate) |
| density | 1.1596 (rough estimate) |
| refractive index | 1.5012 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 15.01±0.30(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White to yellow |
| BRN | 146395 |
| CAS DataBase Reference | 3770-50-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-indole-2-carboxylic acid, ethyl ester(3770-50-1) |
| Safety Information |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| Hazard Note | Keep Cold |
| HazardClass | IRRITANT |
| HS Code | 29339990 |
| MSDS Information |
| Provider | Language |
|---|---|
| Ethyl indole-2-carboxylate | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Ethyl indole-2-carboxylate Usage And Synthesis |
| Chemical Properties | white to yellow crystals or crystalline powder |
| Uses | Reactant for preparation of:• ;CRTH2 receptor antagonists1• ;Indoleamine 2,3-dioxygenase (IDO) inhibitors2• ;Cannabinoid CB1 receptor antagonists3• ;Inhibitors of Human Reticulocyte 15-Lipoxygenase-14• ;N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents5• ;A antiproliferative agent against human leukemia K562 cells6• ;Inhibitors of p38 MAP kinase7• ;Acetolactate synthase inhibitors8 |
| Uses | Reactant for preparation of:CRTH2 receptor antagonists;Indoleamine 2,3-dioxygenase (IDO) inhibitors;Cannabinoid CB1 receptor antagonists; Inhibitors of Human Reticulocyte 15-Lipoxygenase-1;N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents;A antiproliferative agent against human leukemia K562 cells;Inhibitors of p38 MAP kinase; Acetolactate synthase inhibitors. |
| Uses | 2-Ethoxycarbonylindole is a building block that has been used as a reactant for the preparation of pyridazinoindole derivatives that have antimicrobial activities. |
| Synthesis Reference(s) | Chemical and Pharmaceutical Bulletin, 39, p. 1152, 1991 DOI: 10.1248/cpb.39.1152 |
| Ethyl indole-2-carboxylate Preparation Products And Raw materials |
| Preparation Products | 3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID-->1H-INDOL-2-YLMETHANOL-->Methyl 1H-indole-2-carboxylate |
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