5-Bromo-2-methylpyridine Six Chongqing Chemdad Co. ，Ltd

Product

5-Bromo-2-methylpyridine

CAS No.：3430-13-5

Other grades of this product :

5-Bromo-2-methylpyridine Basic information

Product Name:	5-Bromo-2-methylpyridine
Synonyms:	5-broMo-1-Methylpyridine;5--2- MethylpyridinebroMide;2 - Methyl - 5 - broMide pyridine;2-METHYL-5-BROMOPYRIDINE;5-BROMOPICOLINE;3-BROMO-6-METHYLPYRIDINE;5-BROMO-2-METHYLPYRIDINE;5-BROMO-2-PICOLINE
CAS:	3430-13-5
MF:	C6H6BrN
MW:	172.02
EINECS:	625-656-0
Product Categories:	Building Blocks;C6;Pyridines derivates;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;blocks;Bromides;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Bromopyridines;Halopyridines;alkyl bromide
Mol File:	3430-13-5.mol

5-Bromo-2-methylpyridine Chemical Properties

Melting point	32-36 °C
Boiling point	74 °C / 17mmHg
density	1.494±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	3.59±0.10(Predicted)
color	Off-White to Light Yellow Low-Melting
BRN	107324
CAS DataBase Reference	3430-13-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-36-36/37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

5-Bromo-2-methylpyridine Usage And Synthesis

Description	It is an important intermediate in the organic synthesis, which has many applications, such as pharmaceutical intermediate, organic synthesis, organic solvent, production of dyes, pesticide, and spice. Specifically, this chemical can act as the raw material to prepare 2:2’-dipyridyl and its derivatives.¹ Moreover, this compound may be involved in the synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle.² In addition, 5-bromo-2-methylpyridine has been demonstrated to function as the substrate in a general palladium-catalyzed coupling of aryl bromides/triflates and thiols.³ Besides, this substance can facilitate the synthesis of 5-arylamino-2-picolines via displacement of bromide by anthranilic acid and decarboxylation.⁴
Referrence	Willink, H. D. T.; Wibaut, J. P., The preparation of 2 : 2'-dipyridyl and some of its derivatives. Recueil Des Travaux Chimiques Des Pays-Bas 1935, 54, 275-283. Wang, L. H.; Cui, X. L.; Li, J. Y.; Wu, Y. S.; Zhu, Z. W.; Wu, Y. J., Synthesis of Biaryls through a One-Pot Tandem Borylation/Suzuki-Miyaura Cross-Coupling Reaction Catalyzed by a Palladacycle. Eur. J. Org. Chem. 2012, 595-603. Itoh, T.; Mase, T., A general palladium-catalyzed coupling of aryl bromides/triflates and thiols. Org. Lett. 2004, 6, 4587-4590. Louis H. Peterson; Tolman, R. L., Reinvestigation of the synthesis of 5-arylamino-2-picolines J. Heterocycl. Chem. 1977.
Chemical Properties	Light yellow Cryst
Uses	5-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.

5-Bromo-2-methylpyridine Preparation Products And Raw materials

Raw materials	6-Methyl-3-pyridinecarbonyl azide-->Carbamic acid, (6-methyl-3-pyridinyl)-, ethyl ester (9CI)-->2-methylpyridinium chloride-->3-Bromo-2-methylpyridine-->ETHYL 6-METHYLPYRIDINE-3-CARBOXYLATE-->3-Pyridinecarboxylicacid,6-methyl-,hydrazide(9CI)-->5-CYANO-2-METHYLPYRIDINE-->6-METHYLNICOTINAMIDE
Preparation Products	4-AMINO-5-BROMO-2-METHYLPYRIDINE-->5-Bromopyridine-2-carbaldehyde-->2-Hydroxymethyl-5-bromopyridine-->5-BROMO-2-METHYLPYRIDINE N-OXIDE-->6-Methylpyridine-3-boronic Acid-->3-Bromo-2-cyano-6-methylpyridine-->2-Methyl-5-vinylpyridine

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873