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| 5-Bromo-7-azaindole Basic information |
| 5-Bromo-7-azaindole Chemical Properties |
| Melting point | 176-180 °C | | Boiling point | 357.4±42.0 °C(Predicted) | | density | 1.79±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 6.25±0.20(Predicted) | | form | Crystalline Powder | | color | White to yellow | | InChIKey | LPTVWZSQAIDCEB-UHFFFAOYSA-N | | LogP | 1.8 at 25℃ and pH7 | | CAS DataBase Reference | 183208-35-7(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 |
| Provider | Language |
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ALFA
| English |
| 5-Bromo-7-azaindole Usage And Synthesis |
| Chemical Properties | White to light brown powder or crystal | | Uses | 5-Bromo-7-azaindole is a chemical reagent used in organic syntheses. Used in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Also used in other 7-azaindole derivatives such as for PDK1 inihibtors. |
| 5-Bromo-7-azaindole Preparation Products And Raw materials |
| Raw materials | Acetic acid-->Government regulation-->ZINC-->tert-Butanol-->Boron trifluoride diethyl etherate-->7-Azaindole-->Manganese triacetate dihydrate-->1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]--->Acetamide, N-[5-bromo-3-[2-(trimethylsilyl)ethynyl]-2-pyridinyl]--->5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE-->3,3,5-Tribromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one-->2-Aminopyrrole-->5-bromo-3-ethynylpyridin-2-amine-->Methyl 5-bromo-7-azaindole-3-carboxylate-->5-BROMO-3-((TRIMETHYLSILYL)ETHYNYL)PYRIDIN-2-AMINE-->5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-->4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o | | Preparation Products | 1-PropanesulfonaMide, N-[3-[[5-broMo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]- |
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