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| N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Basic information |
| N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical Properties |
| Melting point | 180-182 °C (lit.) | | Boiling point | 501.7±42.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | chloroform: 50 mg/mL | | form | powder | | pka | -2.24±0.20(Predicted) | | color | White to Off-White | | Sensitive | Moisture & Light Sensitive | | BRN | 1555271 | | CAS DataBase Reference | 64987-85-5(CAS DataBase Reference) |
| N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Usage And Synthesis |
| Description | SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. | | Chemical Properties | White Crystalline Solid | | Uses | A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(ab’)2 fragments to ?-galactosidase. Conjugates hIgG to alkaline phosphatase.
Spacer Arm: 11.6 Angstroms | | Uses | A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(ab’)2 fragments to ?-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms | | Definition | ChEBI: An N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. | | General Description | 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. |
| N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Preparation Products And Raw materials |
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