1-ACETYLINDOLINE
1-ACETYLINDOLINE
  • CAS No.:16078-30-1
Other grades of this product :
1-ACETYLINDOLINE Basic information
Product Name:1-ACETYLINDOLINE
Synonyms:1-acetyl-2,3-dihydro-1h-indol;1-acetyl-indolin;1-(2,3-DIHYDRO-1H-INDOL-1-YL)ETHAN-1-ONE;1-(2,3-DIHYDRO-INDOL-1-YL)-ETHANONE;1-ACETYL-2,3-DIHYDROINDOLE;1-ACETYLINDOLINE;Acetylindoline,N-;1H-Indole, 1-acetyl-2,3-dihydro- (9CI)
CAS:16078-30-1
MF:C10H11NO
MW:161.2
EINECS:
Product Categories:Building Blocks;C10;Building Blocks;Heterocyclic Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;ACETYLGROUP;Indoles and derivatives;Indoline & Oxindole;Indoles
Mol File:16078-30-1.mol
1-ACETYLINDOLINE Chemical Properties
Melting point 102-104 °C(lit.)
Boiling point 125-130 °C(Press: 1 Torr)
density 1.144±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka1.13±0.20(Predicted)
CAS DataBase Reference16078-30-1(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS NM1892500
HS Code 2933998090
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
1-ACETYLINDOLINE Usage And Synthesis
Uses• ;Reactant for preparation of triazolothiadiazepine dioxide derivatives1• ;Reactant for preparation of halo-substituted aromatic amides2• ;Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists3• ;Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents4• ;Reactant for regioselective ortho Suzuki-Miyaura coupling reaction5
Uses1-(2,3-Dihydroindol-1-yl)ethanone is an intermediate used for preparation of triazolothiadiazepine dioxide derivatives, halo-substituted aromatic amides and [[(phenyl)piperazinyl]alkyl]indolyl]ethanone.
Uses
  • Reactant for preparation of triazolothiadiazepine dioxide derivatives
  • Reactant for preparation of halo-substituted aromatic amides
  • Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists
  • Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents
  • Reactant for regioselective ortho Suzuki-Miyaura coupling reaction
Synthesis Reference(s)Tetrahedron, 52, p. 7525, 1996 DOI: 10.1016/0040-4020(96)00266-9Tetrahedron Letters, 24, p. 561, 1983 DOI: 10.1016/S0040-4039(00)81464-1
General Description1-Acetylindoline, a substituted indole, is a tertiary amide having bulky N-groups. Its reduction to the corresponding amine, by reaction with silane in the presence of MoO2Cl2 (catalyst), has been reported.
1-ACETYLINDOLINE Preparation Products And Raw materials
Preparation Productsmethyl indoline-5-carboxylate-->5-Bromo-7-nitroindoline-->5-BROMOINDOLINE-->5-Acetylindole

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