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| 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Basic information | | Uses Reactions |
| Product Name: | 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL | | Synonyms: | 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-Di-tert-butylphosphino-2',4',6'-trisopropylbinphenyl;tBuXPhos 97%;2-Di-tert-butyL;phosphino-2',4',6'-triisopropyL;phosphine, bis(1,1-diMethylethyl)[2',4',6'-tris(1-Methylethyl)[1,1'-biphenyl]-2-yl]-;t-Bu XPhos;tBuXPhos | | CAS: | 564483-19-8 | | MF: | C29H45P | | MW: | 424.64 | | EINECS: | 639-817-8 | | Product Categories: | Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts | | Mol File: | 564483-19-8.mol |
| 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Chemical Properties |
| Melting point | 148-151 °C(lit.) | | Boiling point | 493.5±45.0 °C(Predicted) | | solubility | soluble in Toluene | | form | Crystalline Powder | | color | White | | InChIKey | SACNIGZYDTUHKB-UHFFFAOYSA-N |
| 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Usage And Synthesis |
| Uses | tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. tBuXPhos has been used in the preparation of [tBuXPhosAu(MeCN)]BAr4F, a gold catalyst for the intermolecular [2+2] cycloaddition of terminal arylalkynes with substituted alkenes to form functionalized cyclobutenes with high regioselectivity.
tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.
It can be used in the following reactions:
• Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
• Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
• Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones. | | Reactions |
- Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles.
- Ligand used in the Pd-catalyzed synthesis of phenols from aryl halides and KOH.
- Ligand used in the Pd-catalyzed of benzoic acids from aryl halides and CO2.
- Ligand used in the Pd-catalyzed trifluoromethylation of vinyl sulfonates.
- Ligand used in the Pd-catalyzed arylation of nitroacetates.
- Ligand used in the Pd-catalyzed Suzuki−Miyaura cross-coupling of allylboronates and aryl halides.
- Ligand used in the Pd-catalyzed cyanation of (hetero)arylchlorides and bromides.
- Ligand used in the Pd-catalyzed C–N cross coupling of sulfinamides and aryl halides.
- Ligand used in the Pd-catalyzed arylation of cyanamides.
| | Chemical Properties | White to pale yellow | | Uses | Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles | | Uses | tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.It can be used in the following reactions:- Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
- Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
- Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.
| | Uses | suzuki reaction | | General Description | tBuXPhos[2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. |
| 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Preparation Products And Raw materials |
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