• CAS No.:88-05-1
Other grades of this product :
2,4,6-Trimethylaniline Basic information
Product Name:2,4,6-Trimethylaniline
Synonyms:2,4,6-Trimethylanyline;2,4,6-Trimethylaniline,97%;2,4,6-trimethylaniline98%;2,4,6-Trimethylanili;2,4,6-TriMethylaniline, 97% 100GR;Aminomesitylene 2-Amino-1,3,5-trimethylbenzene Mesidine Mesitylamine;2,4,6-TRIMETHYLANILINE FOR SYNTHESIS;2 Minus 2-3 Methylaniline
Product Categories:API intermediates;Intermediates of Dyes and Pigments
Mol File:88-05-1.mol
2,4,6-Trimethylaniline Chemical Properties
Melting point -5 °C
Boiling point 108-110 °C11 mm Hg(lit.)
density 0.963 g/mL at 25 °C(lit.)
refractive index n20/D 1.551(lit.)
Fp 205 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pkapK1:4.38(+1) (25°C)
form liquid (clear)
color clear brown
Water Solubility IMMISCIBLE
BRN 636559
CAS DataBase Reference88-05-1(CAS DataBase Reference)
IARC3 (Vol. 27, Sup 7) 1987
NIST Chemistry ReferenceBenzenamine, 2,4,6-trimethyl-(88-05-1)
EPA Substance Registry System2,4,6-Trimethylaniline (88-05-1)
Safety Information
Hazard Codes T+,T
Risk Statements 21/22-26-36/38-33-23/24/25
Safety Statements 26-28-36/37-45-28A
RIDADR UN 2810 6.1/PG 2
WGK Germany 3
RTECS BZ0700000
HazardClass 6.1
PackingGroup III
HS Code 29214980
Hazardous Substances Data88-05-1(Hazardous Substances Data)
MSDS Information
2,4,6-Trimethylbenzenamine English
SigmaAldrich English
ACROS English
ALFA English
2,4,6-Trimethylaniline Usage And Synthesis
Chemical Propertiesclear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.
Uses2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.
Preparation2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.
General Description2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.
Reactivity Profile2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.
Fire HazardWhen heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.
Safety ProfilePoison by inhalation. Moderately toxic by ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Potential ExposureUsed on small scale in organic synthesis.
ShippingUN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.


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