| 2,2'-Dithiodipyridine Basic information |
| Product Name: | 2,2'-Dithiodipyridine |
| Synonyms: | NSC 94055;1,2-Di(pyridin-2-yl)disulfane;2,2'-Disulphanediyldipyridine, 2,2'-Dithiodipyridine;Di(pyridin-2-yl) disulphide;Aldrithiol(TM)-2 98%;1,2-Di(pyridin-2-yl)disulfide;2-(2-Pyridinyldisulfanyl)pyridine;2,2'-Dipyridinyl disulfide |
| CAS: | 2127-03-9 |
| MF: | C10H8N2S2 |
| MW: | 220.31 |
| EINECS: | 218-343-1 |
| Product Categories: | Aromatics;Heterocycles;Peptide Synthesis;Synthetic Organic Chemistry;Miscellaneous Reagents;Sulfur & Selenium Compounds;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis) |
| Mol File: | 2127-03-9.mol |
| 2,2'-Dithiodipyridine Chemical Properties |
| Melting point | 56-58 °C(lit.) |
| Boiling point | 356.1±17.0 °C(Predicted) |
| density | 1.3078 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Fp | 210 °C |
| storage temp. | 2-8°C |
| solubility | methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow |
| form | powder |
| pka | 1.52±0.19(Predicted) |
| color | Clear colorless to yellow to tan |
| Water Solubility | 5 g/L (20 ºC) |
| BRN | 154629 |
| InChIKey | HAXFWIACAGNFHA-UHFFFAOYSA-N |
| CAS DataBase Reference | 2127-03-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2,2'-dithiobis-(2127-03-9) |
| EPA Substance Registry System | Pyridine, 2,2'-dithiobis- (2127-03-9) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-37-20/22 |
| Safety Statements | 36/37/39-37/39-25-22-36-26 |
| RIDADR | UN 3335 |
| WGK Germany | 3 |
| F | 10-23 |
| Autoignition Temperature | 340 °C |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29333990 |
| MSDS Information |
| Provider | Language |
|---|---|
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| 2,2'-Dithiodipyridine Usage And Synthesis |
| Chemical Properties | white to yellowish crystalline powder |
| Uses | 2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine. |
| Uses | 2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides. |
| Uses | Aldrithiol?-2 was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation. |
| General Description | Aldrithiol?-2 is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1virions. It is a thiol reagent. |
| Biochem/physiol Actions | 2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives. |
| Purification Methods | Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare |
| 2,2'-Dithiodipyridine Preparation Products And Raw materials |
| Raw materials | Pyrithione-->Bispyrithione |
| Preparation Products | Finasteride-->PYRIDINE-2-SULFONYL CHLORIDE-->Pyridine,2-(2-propen-1-ylthio)--->2-Pyridinesulfonamide(6CI,7CI,9CI)-->2-Methylthiopyridine |
Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.
日本语
한국어
Français
Deutsch
España
Türkiye