• CAS No.:2127-03-9
Other grades of this product :
2,2'-Dithiodipyridine Basic information
Product Name:2,2'-Dithiodipyridine
Synonyms:NSC 94055;1,2-Di(pyridin-2-yl)disulfane;2,2'-Disulphanediyldipyridine, 2,2'-Dithiodipyridine;Di(pyridin-2-yl) disulphide;Aldrithiol(TM)-2 98%;1,2-Di(pyridin-2-yl)disulfide;2-(2-Pyridinyldisulfanyl)pyridine;2,2'-Dipyridinyl disulfide
Product Categories:Aromatics;Heterocycles;Peptide Synthesis;Synthetic Organic Chemistry;Miscellaneous Reagents;Sulfur & Selenium Compounds;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis)
Mol File:2127-03-9.mol
2,2'-Dithiodipyridine Chemical Properties
Melting point 56-58 °C(lit.)
Boiling point 356.1±17.0 °C(Predicted)
density 1.3078 (rough estimate)
refractive index 1.5500 (estimate)
Fp 210 °C
storage temp. 2-8°C
solubility methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
form powder
color Clear colorless to yellow to tan
Water Solubility 5 g/L (20 ºC)
BRN 154629
CAS DataBase Reference2127-03-9(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 2,2'-dithiobis-(2127-03-9)
EPA Substance Registry SystemPyridine, 2,2'-dithiobis- (2127-03-9)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-37-20/22
Safety Statements 36/37/39-37/39-25-22-36-26
WGK Germany 3
Autoignition Temperature340 °C
Hazard Note Irritant
HS Code 29333990
MSDS Information
ACROS English
SigmaAldrich English
ALFA English
2,2'-Dithiodipyridine Usage And Synthesis
Chemical Propertieswhite to yellowish crystalline powder
Uses2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine.
Uses2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides.
UsesAldrithiol?-2 was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.
General DescriptionAldrithiol?-2 is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1virions. It is a thiol reagent.
Biochem/physiol Actions2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.
Purification MethodsRecrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare
2,2'-Dithiodipyridine Preparation Products And Raw materials
Raw materialsPyrithione-->Bispyrithione
Preparation ProductsFinasteride-->PYRIDINE-2-SULFONYL CHLORIDE-->Pyridine,2-(2-propen-1-ylthio)--->2-Pyridinesulfonamide(6CI,7CI,9CI)-->2-Methylthiopyridine


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