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| L(-)-Pipecolinic acid Chemical Properties |
| Melting point | 272 °C(lit.) | | alpha | -27.5 º (c=5, H2O 24 ºC) | | Boiling point | 239.22°C (rough estimate) | | density | 1.1426 (rough estimate) | | refractive index | -27 ° (C=4, H2O) | | storage temp. | 2-8°C | | pka | 2.28(at 25℃) | | form | Fine Crystalline Powder | | color | White | | optical activity | [α]25/D 26.4°, c = 1 in H2O | | Water Solubility | soluble | | Merck | 14,7458 | | BRN | 81093 | | InChIKey | HXEACLLIILLPRG-YFKPBYRVSA-N | | CAS DataBase Reference | 3105-95-1(CAS DataBase Reference) |
| L(-)-Pipecolinic acid Usage And Synthesis |
| Description | L-Pipecolinic acid is involved in synaptic transmission in the central nervous system. It is also used as pharmaceutical intermediate. It is a lysine metabolite; defect in its catabolism is involved in hyperpipecolic acidemia, cerebro-hepato-renal syndrome, neonatal onset adrenoleukodystrophy, and infantile Refsum disease. It can be associated with some forms of epilepsy. CRYM, a taxon-specific crystallin protein that also binds thyroid hormones, is involved in the pipecolic acid pathway.
| | Chemical Properties | white to light yellow crystal powde | | Uses | Pipecolic acid is involved in synaptic transmission in the central nervous system. The l-form occurs in plants. | | Uses | L-Pipecolinic acid is involved in synaptic transmission in the central nervous system. It is also used as pharmaceutical intermediate. | | Definition | ChEBI: A pipecolate that is the conjugate acid of L--pipecolic acid. | | General Description | Occurs in seeds, malt, edible mushrooms, fruits, etc. | | Biochem/physiol Actions | L-pipecolic acid is implicated in Zellweger syndrome. Pipecolic acid is also a plant defence metabolite. It is a signaling compound essential for systemic acquired resistance (SAR). | | Purification Methods | It crystallises from water. The (±)-picrate has m 158-159o (from EtOH or C6H6). [Beilstein 22 H 7, 22 III/IV 97, 22/1 V 220.] The R(+)-enantiomer [1723-00-8] has m 277o(dec) and [] D 20 +27o (c 4, H2O), and the S(-)-enantiomer [3105-95-1] has m 277o(dec) and [] D 20 -26o (c 4, H2O).[cf p 603, Beilstein 22 III/IV 96, 22/1 V 220.] |
| L(-)-Pipecolinic acid Preparation Products And Raw materials |
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