N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Five Chongqing Chemdad Co. ，Ltd

Product

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

CAS No.：1139453-98-7

Other grades of this product :

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Basic information

Product Name:	N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Synonyms:	Nidanib Impurity 12: N-methyl-2- (4-methylpiperazin-1-yl) -N- (4-nitrophenyl) -acetamide;N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide;N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide;Nintedanib impurity 2/N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;Nintedanib Intermediate 1;Intedanib Impurity 12;Nintedanib-003
CAS:	1139453-98-7
MF:	C14H20N4O3
MW:	292.33
EINECS:
Product Categories:	Intermediate of BIBF-1120 and PKI587
Mol File:	1139453-98-7.mol

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Chemical Properties

Melting point	94 - 96°C
Boiling point	446.9±40.0 °C(Predicted)
density	1.230
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.43±0.10(Predicted)
form	Solid
color	Pale Yellow to Light Yellow

Safety Information

MSDS Information

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Usage And Synthesis

Uses	N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide is used as a reactant in the synthetic preparation of 6-methoxycarbonyl-substituted indolinones, such as Intedanib (I666650), which is a triple angiokinase inhibitor and antitumor agent.

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Preparation Products And Raw materials

Raw materials	2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide-->2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE-->1-Bromo-4-nitrobenzene-->1-Methylpiperazine-->N-Methyl-4-nitroaniline
Preparation Products	(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873