| ALPHA-HELICAL CRF (9-41) Basic information |
| Product Name: | ALPHA-HELICAL CRF (9-41) |
| Synonyms: | CORTICOTROPIN RELEASING FACTOR ANTAGONIST;H-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2;ASP-LEU-THR-PHE-HIS-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-ALA-GLU-GLN-ALA-LEU-ASN-ARG-LEU-LEU-GLU-ALA-NH2;ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2;ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR;α-helical corticotropin releasing factor fragment (9-41);ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41);ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR FRAGMENT (9-41) |
| CAS: | 99658-03-4 |
| MF: | C22H25IN2O6 |
| MW: | 540.34817 |
| EINECS: | |
| Product Categories: | CRF receptor and related |
| Mol File: | 99658-03-4.mol |
| ALPHA-HELICAL CRF (9-41) Chemical Properties |
| storage temp. | −20°C |
| form | powder |
| color | white |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALPHA-HELICAL CRF (9-41) Usage And Synthesis |
| Biochem/physiol Actions | The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion. |
| ALPHA-HELICAL CRF (9-41) Preparation Products And Raw materials |
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