Other grades of this product :
| MERBARONE Basic information |
| Product Name: | MERBARONE | | Synonyms: | 4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;MERBARONE | | CAS: | 97534-21-9 | | MF: | C11H9N3O3S | | MW: | 263.27 | | EINECS: | | Product Categories: | | Mol File: | 97534-21-9.mol |
| MERBARONE Chemical Properties |
| density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >5mg/mL | | form | solid | | pka | -2.16±0.20(Predicted) |
| WGK Germany | 3 | | RTECS | UV7714625 |
| MERBARONE Usage And Synthesis |
| Uses | Merbarone has been used to study its effect on the occurrence of DNA lesions. | | General Description | A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism. | | Biochem/physiol Actions | Cell permeable: yes |
| MERBARONE Preparation Products And Raw materials |
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