GLY-ARG-GLY-ASP-SER

CAS No.：96426-21-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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GLY-ARG-GLY-ASP-SER Basic information

Product Name:	GLY-ARG-GLY-ASP-SER
Synonyms:	GRGDS;GRGDS 1/2ACOH 2H2O;GRGDS, FIBRONECTIN ATTACHMENT PEPTIDE;GLY-ARG-GLY-ASP-SER;GLY-ARG-GLY-ASP-SER 1/2ACOH 2H2O;H-GLY-ARG-GLY-ASP-SER-OH;L-Serine, N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-;glycyl-arginyl-glycyl-aspartyl-serine
CAS:	96426-21-0
MF:	C17H30N8O9
MW:	490.47
EINECS:
Product Categories:	Cell Signaling Enzymes;ECM Related Proteins and PeptidesCytoskeleton and Extracellular Matrix;Extracellular Matrix;Extracellular Matrix Peptides (ECM);Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology;Fibronectin Fragments and Analogs;Matrix Metalloproteinases Products;peptide
Mol File:	96426-21-0.mol

GLY-ARG-GLY-ASP-SER Chemical Properties

density	1.66±0.1 g/cm3(Predicted)
storage temp.	-20°C
form	White to off-white lyophilized solid
pka	2.85±0.10(Predicted)

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

GLY-ARG-GLY-ASP-SER Usage And Synthesis

Uses	Gly-Arg-Gly-Asp-Ser has been used- as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1⁺ progenitor cell differentiation into SMCs (smooth muscle cells) as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus
General Description	Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.
Biochem/physiol Actions	Antagonist of integrin function

GLY-ARG-GLY-ASP-SER Preparation Products And Raw materials

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