2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

CAS No.：946387-07-1

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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Basic information

Product Name:	2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Synonyms:	2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;RN 1734;2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
CAS:	946387-07-1
MF:	C14H22Cl2N2O2S
MW:	353.31
EINECS:
Product Categories:
Mol File:	946387-07-1.mol

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties

storage temp.	2-8°C
solubility	DMSO: >20mg/mL
form	Yellow solid
color	white to off-white

Safety Information

WGK Germany

nwg

MSDS Information

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Usage And Synthesis

Uses	RN 1734 is a novel TRPV4 modulator.
Uses	RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.
General Description	A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca²⁺ influx (IC₅₀ = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC₅₀ >30 μM).
Biological Activity	Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).
Biochem/physiol Actions	RN-1734 is a selective TRPV4 antagonist.

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Preparation Products And Raw materials

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