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| NSC 95397 Basic information |
| Product Name: | NSC 95397 | | Synonyms: | 2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE;2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE;2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE;1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-;Cdc25 Inhibitor IV, NSC 95397;NSC 95397;Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem | | CAS: | 93718-83-3 | | MF: | C14H14O4S2 | | MW: | 310.39 | | EINECS: | | Product Categories: | Protein Phosphatase | | Mol File: | 93718-83-3.mol |
| NSC 95397 Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 16 mg/mL | | form | Orange solid | | color | orange, solid | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Codes | Xi | | WGK Germany | 3 | | HazardClass | IRRITANT |
| NSC 95397 Usage And Synthesis |
| Description | NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki? = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4 | | Uses | NSC 95397 is a quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor. | | Biological Activity | Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (K i values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125-180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G 2 /M phase transition in vitro . | | Biochem/physiol Actions | Irreversible Cdc25 dual specificity phosphatase inhibitor. | | References | 1) Lazo et al. (2002), Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors; Mol. Pharmacol., 61 720
2) Melchheier et al. (2005), Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation; Biochem. Biophys. Res. Commun., 327 1016
3) Blevins et al. (2015), Small Molecule, NSC95397, inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression; J. Biomol. Screen., 20 663
4) Jemaa et al. (2016), Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397; Cell. Physiol. Biochem., 40 597 |
| NSC 95397 Preparation Products And Raw materials |
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