| FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID Basic information |
| Product Name: | FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID |
| Synonyms: | Fmoc-2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid≥ 98% (HPLC);FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID;FMOC-TOAC;FMOC-TOAC-OH 100 MG;FMOC-TOAC-OH 500 MG;4-(9H-fluoren-9-ylmethoxycarbonylamino)-2,2,6,6-tetramethyl-1-oxidopiperidin-1-ium-4-carboxylic acid |
| CAS: | 93372-25-9 |
| MF: | C25H29N2O5* |
| MW: | 437.51 |
| EINECS: | |
| Product Categories: | Chiral Reagents;Spin Labeling Compounds |
| Mol File: | Mol File |
| FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID Chemical Properties |
| Melting point | 162-164°C |
| storage temp. | Store at +2°C to +8°C. |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Yellow to Yellow |
| Safety Information |
| WGK Germany | WGK 2 water endangering |
| HS Code | 2933 39 99 |
| MSDS Information |
| FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | Yellow Solid |
| Uses | A protected spin-labelled, cyclic, chiral ?amino acid resolved in an enantiomerically pure state |
| Uses | A stable free radical spin label. |
| Uses | Fmoc-2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic Acid is a stable, free radical spin label. |
| General Description | Fmoc-TOAC-OH is a useful tool for the incorporation of the ESR spin-label TOAC into peptide sequences [1]. Incorporation of this derivative and the following residue is best achieved using HATU activation. TFA/water/TIS should be used for cleavage of TOAC-containing peptides. The use of EDT should be avoided as it can cause permanent reduction of the nitroxide radical [2]. Following cleavage, the TOAC peptide should be treated with aqueous ammonia in air to regenerate the nitroxide from the hydroxylamine that is generated by the TFA treatment. |
| FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID Preparation Products And Raw materials |
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