3-METHOXY-2-NAPHTHOIC ACID

CAS No.：883-62-5

Other grades of this product :

3-METHOXY-2-NAPHTHOIC ACID Basic information

Product Name:	3-METHOXY-2-NAPHTHOIC ACID
Synonyms:	3-methoxy-2-naphthalenecarboxylicaci;3-Methoxy-2-naphthoic acid 98%;3-Methoxy-naphthalene-2-carboxylic acid;3-Methoxy-2-naphthalenecarboxylic acid;2-Methoxy-3-naphthoic acid;2-Naphthalenecarboxylic acid, 3-methoxy-;2-Naphthoic acid, 3-methoxy-;Einecs 212-932-7
CAS:	883-62-5
MF:	C12H10O3
MW:	202.21
EINECS:	212-932-7
Product Categories:	C11 to C12;Carbonyl Compounds;Carboxylic Acids
Mol File:	883-62-5.mol

3-METHOXY-2-NAPHTHOIC ACID Chemical Properties

Melting point	133-136 °C (lit.)
Boiling point	358.8±17.0 °C(Predicted)
density	1.263±0.06 g/cm3(Predicted)
solubility	soluble in Methanol
form	powder to crystal
pka	4.09±0.30(Predicted)
color	Light orange to Yellow to Green
EPA Substance Registry System	2-Naphthalenecarboxylic acid, 3-methoxy- (883-62-5)

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

3-METHOXY-2-NAPHTHOIC ACID Usage And Synthesis

Uses

3-Methoxy-2-naphthoic acid may be used in the synthesis of N-[p-N,N-dimethylanilino)-3-methoxy-2-naphtho]hydroxamic acid (DAMNHA).

General Description

3-Methoxy-2-naphthoic acid is a naphthoic acid derivative. 3-Methoxy-2-naphthoic acid can be prepared from 3-hydroxy-2-naphthoic acid, via methylation. It undergoes reduction under the following reaction conditions:

in the presence of Li and NH₄Cl to afford 1,2,3,4-tetrahydro-2-naphthoic acid
by using Li, NH₄Cl and anhydrous FeCl₃ to afford 3-methoxy-1, 2-dihydro-2-naphthoic acid
in anhydrous ether, liquid ammonia, lithium wire and anhydrous ethanol to afford 1,2,3,4-tetrahydro-2-naphthoic acid

3-METHOXY-2-NAPHTHOIC ACID Preparation Products And Raw materials

Raw materials	3-Methoxy-2-naphthoyl chloride-->METHYL 3-METHOXY-2-NAPHTHOATE-->METHYL 3-HYDROXY-2-NAPHTHOATE-->3-Hydroxy-2-naphthoic acid-->CARBON DIOXIDE-->Dimethyl sulfate-->Iodomethane-->2-Methoxynaphthalene
Preparation Products	2-METHOXY-1-NAPHTHOIC ACID-->2-Bromo-3-methoxynaphthalene-->2-Hydroxypyridine-->3-AMINO-2-NAPHTHOL

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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