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| N-DESMETHYLCLOZAPINE Basic information |
| Product Name: | N-DESMETHYLCLOZAPINE | | Synonyms: | N-DESMETHYLCLOZAPINE;NORCLOZAPINE;8-CHLORO-11-(1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE;8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE;8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZEPINE;CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC;8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine;Desmethylclozapine | | CAS: | 6104-71-8 | | MF: | C17H17ClN4 | | MW: | 312.8 | | EINECS: | 636-421-7 | | Product Categories: | Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Serotonin receptor;Miscellaneous | | Mol File: | 6104-71-8.mol |
| N-DESMETHYLCLOZAPINE Chemical Properties |
| Melting point | 120-125°C | | Boiling point | 502.6±60.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | Store at RT | | solubility | Chloroform (Slightly), DMSO, Methanol (Slightly) | | pka | 8.49±0.10(Predicted) | | form | Yellow solid. | | color | Light Yellow to Yellow | | CAS DataBase Reference | 6104-71-8(CAS DataBase Reference) |
| N-DESMETHYLCLOZAPINE Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid | | Uses | A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist. | | Uses | N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients. | | Uses | A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist. | | Definition | ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist. | | General Description | N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS. | | Biological Activity | A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist. | | Biochem/physiol Actions | N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors. |
| N-DESMETHYLCLOZAPINE Preparation Products And Raw materials |
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