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| METHOPRENE ACID Basic information |
| Product Name: | METHOPRENE ACID | | Synonyms: | 11-methoxy-3,7,11-trimethyl-,(e,e)-(+/-)-4-dodecadienoicacid;(2E,4E)-(±)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoic acid;(+-)-(2E,4E)-11-Methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid;(2E,4E)-(1)-11-Methoxy-3,7,11-trimethyldodeca-2,4-dienoic acid;2,4-Dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, (2E,4E)-;Einecs 258-355-4;Methoprene acid >=98% (TLC) | | CAS: | 53092-52-7 | | MF: | C16H28O3 | | MW: | 268.39 | | EINECS: | 258-355-4 | | Product Categories: | | Mol File: | 53092-52-7.mol |
| METHOPRENE ACID Chemical Properties |
| Boiling point | 394.1±25.0 °C(Predicted) | | density | 0.954±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO or Ethanol | | form | Pale yellow oil. | | pka | 4.96±0.33(Predicted) | | color | Colorless | | Stability: | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | EPA Substance Registry System | 2,4-Dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, (2E,4E)- (53092-52-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | Yes |
| METHOPRENE ACID Usage And Synthesis |
| Description | Methoprene Acid (53093-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to the retinoid X receptor (RXR) acting as a transcriptional activator in both insect and mammalian cells with no activity at RAR.1?Negatively regulates thrombosis and hemostasis.2?Induces neurosteroid biosynthesis in human glial GI-1 cells.3?Increases the expression of the brown-fat-uncoupling-protein-1 gene (ucp-1).4 | | Uses | Methoprene Acid is an analog of insect juvenile hormone which acts as an insect growth regulator. | | General Description | Retinoic acid receptor (RXR) agonist used in gene regulation research. Analog of juvenile hormone, an insect growth hormone. | | Biochem/physiol Actions | Demethylation, oxidative cleavage, hydrolysis, photodegradation and degradation of methoprene by microorganism results in methoprene acid and other metabolites. Methoprene acid is an insect growth regulator, and is known to control ecdysteroid signaling during development and metamorphism. It is thus used to control larval growth in insects such as mosquitoes, cigarette beetles, fleas and fire ants. | | References | 1) Harmon?et al.?(1995),?Activation of mammalian retinoid X receptors by the insect growth regulator methoprene; Proc. Natl. Acad. Sci. USA,?92?6157
2) Unsworth?et al.?(2017),?RXR Ligands Negatively Regulate Thrombosis and Hemostasis; Arterioscler. Thromb. Vasc. Biol.,?37?812
3) Kushida and Tamura (2009),?Retinoic acids induce neurosteroid biosynthesis in human glial GL-1 cells via the induction of steroidogenic genes; J. Biochem.,?146?917
4) Alvarez?et al. (2000),?Both retinoic-acid-receptor and retinoid-X-receptor-dependent signaling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids; Biochem. J.,?345 Pt 1?91 |
| METHOPRENE ACID Preparation Products And Raw materials |
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