ATROPINE METHYL NITRATE
ATROPINE METHYL NITRATE
  • CAS No.:52-88-0
Other grades of this product :
ATROPINE METHYL NITRATE Basic information
Product Name:ATROPINE METHYL NITRATE
Synonyms:metropine;n-methylatropinenitrate;N-METHYLATROPINIUM NITRATE;,endo-(+/-)-,nitrate(salt);1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-methyl-,nitrate,(+-)-tropa;3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromide(+,-)-tropate;8-methylatropiniumnitrate;8-methyl-atropiniunitrate
CAS:52-88-0
MF:C18H26N2O6
MW:366.41
EINECS:200-156-1
Product Categories:Alkaloids;Biochemistry;Tropane Alkaloids
Mol File:52-88-0.mol
ATROPINE METHYL NITRATE Chemical Properties
Melting point 163°C
storage temp. -20°C
solubility H2O: 50 mg/mL
form powder
color white
Merck 875
CAS DataBase Reference52-88-0(CAS DataBase Reference)
EPA Substance Registry SystemMethylatropine nitrate (52-88-0)
Safety Information
Hazard Codes Xn,T+
Risk Statements 22-26/28
Safety Statements 22-36-45-25
RIDADR 1544
WGK Germany 3
RTECS CK2800000
ToxicityLD50 oral in rat: 1902mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ATROPINE METHYL NITRATE Usage And Synthesis
Chemical Propertiesmp 162-164 C
OriginatorMethylatropine,Paganfarma
Usesantibacterial
Usescephalosporin antimicrobial
UsesAtropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.
Manufacturing ProcessThere are 2 methods of synthesis of methyl atropine nitrate: 1) To a solution of 28.9 g atropine of in 100 g of methanol was added at 110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl atropine nitrate was crystallysed, M.P. 163°C. 2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl atropine chloride and silver nitrate) in water was added aqueous solution of 26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was concentrated and the methyl atropine nitrate was obtained.
Brand nameEkomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).
Therapeutic FunctionAnticholinergic, Mydriatic, Spasmolytic
Biochem/physiol ActionsAtropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.
Safety ProfilePoison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.
ATROPINE METHYL NITRATE Preparation Products And Raw materials
Raw materialsAtropine sulfate-->Atropine-->Barium nitrate-->Methyl nitrate-->methyl nitrate-->Methyl bromide

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