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| Product Name: | SU 16f | | Synonyms: | 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl- | | CAS: | 251356-45-3 | | MF: | C24H22N2O3 | | MW: | 386.44 | | EINECS: | | Product Categories: | Angiogenesis and Metastasis | | Mol File: | 251356-45-3.mol |
| SU 16f Chemical Properties |
| Boiling point | 661.7±55.0 °C(Predicted) | | density | 1.292±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | form | Dark orange solid | | pka | 4?+-.0.10(Predicted) |
| SU 16f Usage And Synthesis |
| Uses | SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor. | | General Description | A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM). |
| SU 16f Preparation Products And Raw materials |
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