Other grades of this product :
| Propargyl-PEG6-acid Basic information |
| Product Name: | Propargyl-PEG6-acid | | Synonyms: | Propargyl-PEG6-acid;Propyne-PEG5-CH2CH2COOH;Propargyl-PEG5-CH2CH2COOH;CAS_1951438-84-8;4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid;Propargyl-PEG6-Propionic Acid | | CAS: | 1951438-84-8 | | MF: | C16H28O8 | | MW: | 348.39 | | EINECS: | | Product Categories: | peg | | Mol File: | 1951438-84-8.mol |
| Propargyl-PEG6-acid Chemical Properties |
| Boiling point | 462.8±45.0 °C(Predicted) | | density | 1.126±0.06 g/cm3(Predicted) | | refractive index | n/D 1.469 | | storage temp. | -20°C | | solubility | Soluble in Water | | form | liquid | | pka | 4.28±0.10(Predicted) |
| Propargyl-PEG6-acid Usage And Synthesis |
| Description | Propargyl-PEG6-acid comprises propargyl and carboxylic acid functional groups. The acid group reacts with primary amines in the presence of activators (e.g. EDC, or HATU).The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The molecule has good solubility in aqueous environment. | | Uses | This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Propargyl-PEG6-acid Preparation Products And Raw materials |
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