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| RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Basic information |
| Product Name: | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE | | Synonyms: | RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-bromo-PET-Cyclic GMPS (sodium salt);Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder;Rp-8-bromo-PET-Cyclic GMPS sodium | | CAS: | 185246-32-6 | | MF: | C18H14BrN5NaO6PS | | MW: | 562.266 | | EINECS: | | Product Categories: | | Mol File: | 185246-32-6.mol |
| RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Chemical Properties |
| Melting point | 240-300 °C(lit.) | | storage temp. | -20°C | | solubility | H2O: soluble15mg/mL at ≤60°C | | form | powder | | color | white to beige |
| RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Usage And Synthesis |
| Description | Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11. | | Uses | Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI). | | Biochem/physiol Actions | Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles). |
| RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Preparation Products And Raw materials |
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