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| 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Basic information |
| 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Chemical Properties |
| Melting point | 266 °C(dec.) | | storage temp. | 2-8°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Codes | Xn,N | | Risk Statements | 22-50 | | Safety Statements | 61 | | WGK Germany | 3 |
| 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Usage And Synthesis |
| Description | ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2 | | Uses | ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture. | | General Description | ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). | | Biochem/physiol Actions | ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period). | | References | 1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242
2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18 |
| 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Preparation Products And Raw materials |
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