Other grades of this product :
| Bromo-PEG1-Acid Basic information |
| Product Name: | Bromo-PEG1-Acid | | Synonyms: | Bromo-PEG1-propionic acid;Bromo-PEG1-Acid;CAS_1393330-33-0;Br-PEG1-CH2CH2COOH;3-(2-Bromoethoxy)propanoic acid;Propanoic acid, 3-(2-bromoethoxy)-;Bromo-PEG1-acid >=95% | | CAS: | 1393330-33-0 | | MF: | C5H9BrO3 | | MW: | 197.03 | | EINECS: | | Product Categories: | | Mol File: | 1393330-33-0.mol |
| Bromo-PEG1-Acid Chemical Properties |
| Bromo-PEG1-Acid Usage And Synthesis |
| Description | Bromo-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Bromo-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Bromo-PEG1-Acid Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye