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| 4-Hydroxy Cholesterol-d7 Basic information |
| Product Name: | 4-Hydroxy Cholesterol-d7 | | Synonyms: | 4-Hydroxy Cholesterol-d7;CHOLEST-5-ENE-3,4-DIOL-D7;4-HYDROXYCHOLESTEROL-D7;(3S,4R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6,7,7,7-tetradeuterio-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,4-diol;4-beta-Hydroxy Cholesterol-d7;cholest-5-ene-3,4-diol-d7;4β-Hydroxy Cholesterol-d7 | | CAS: | 1246302-80-6 | | MF: | C27H46O2 | | MW: | 402.65294 | | EINECS: | | Product Categories: | Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Steroids;Isotope Labelled Compounds, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids | | Mol File: | 1246302-80-6.mol |
| 4-Hydroxy Cholesterol-d7 Chemical Properties |
| Melting point | 154-159°C | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated) | | form | Solid | | color | White to Off-White |
| 4-Hydroxy Cholesterol-d7 Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 4β-Hydroxy Cholesterol-d7 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential
and also a new endogenous CYP3A marker. | | Uses | 4β-Hydroxy Cholesterol-d7 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. | | Uses | 4β-hydroxycholesterol-d7 has been used: - as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
- to spike serum samples for mass spectrometry measurements
- as an internal standard for the quantification of human colon biopsies samples using HPLC-MS
| | General Description | 4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol. | | Biochem/physiol Actions | 4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation. |
| 4-Hydroxy Cholesterol-d7 Preparation Products And Raw materials |
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