3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
  • CAS No.:1235397-05-3
Other grades of this product :
3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Basic information
Product Name:3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
Synonyms:3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide;PF-04856264;3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide;3-CYANO-4-(2-(1-METHYL-1H-PYRAZOL-5-YL) PHENOXY)-N-(THIAZOL-2-YL) BENZENESULFONAMIDE;PF-04856264 >=98% (HPLC);PF 4856264;PF4856264;PF-4856264
CAS:1235397-05-3
MF:C20H15N5O3S2
MW:437.49
EINECS:
Product Categories:
Mol File:1235397-05-3.mol
3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Chemical Properties
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
color white to light brown
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Usage And Synthesis
Biochem/physiol ActionsPF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC50 = 131 nM) but has low potency against the rat Nav1.7 channel (IC50 = 4.2 mM).
3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Preparation Products And Raw materials

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