3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Three Chongqing Chemdad Co. ，Ltd

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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

CAS No.：1164470-53-4

Other grades of this product :

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Basic information

Product Name:	3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Synonyms:	SAL-003;SAL 003;SAL003;CS-1897;(2E)-3-Phenyl-N-(2;2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide;SAL003;(2E)-3-PHENYL-N-(2;2;2-TRICHLORO-1-{[(4-CHLOROPHENYL)CARBAMOTHIOYL]AMINO}ETHYL)ACRYLAMIDE;eIF-2α Inhibitor II, Sal003;3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide;Sal 003
CAS:	1164470-53-4
MF:	C18H15Cl4N3OS
MW:	463.21
EINECS:
Product Categories:	Inhibitors
Mol File:	1164470-53-4.mol

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Chemical Properties

storage temp.	2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to off-white

Safety Information

Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

MSDS Information

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Usage And Synthesis

Uses	Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.
Biological Activity	eukaryotic initiation factor 2 α-subunit (eif2α) plays a critical role in the regulation of protein synthesis. moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. sal003 is a selective inhibitor of eif2α dephosphorylation.
Biochem/physiol Actions	Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.
in vitro	sal003 specifically prevents dephosphorylation of eif2α by blocking eif2α phosphatases. in sal003-treated cells polysomes dissociated and consistent with this β-actin mrna shifted to lighter fractions, reflecting the inhibition of general translation [1].
in vivo	intra-basolateral amygdala (bla) infusions of sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced cpp, leading to a long-lasting suppression of drug-paired stimulus-induced craving. moreover, inhibition of eif2α dephosphorylation in the bla immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. these results demonstrate that eif2α dephosphorylation in the bla mediates the memory reconsolidation of drug-paired stimuli [1].
references	[1] jian m, luo yx, xue yx, han y, shi hs, liu jf, yan w, wu p, meng sq, deng jh, shen hw, shi j, lu l. eif2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. j neurosci. 2014;34(30):10010-21.

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Preparation Products And Raw materials

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