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| PHENAMIL METHANESULFONATE Basic information |
| PHENAMIL METHANESULFONATE Chemical Properties |
| storage temp. | 2-8°C | | solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL | | form | solid | | color | yellow | | CAS DataBase Reference | 1161-94-0 |
| PHENAMIL METHANESULFONATE Usage And Synthesis |
| Chemical Properties | off-white to yellow solid | | Uses | Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte | | Uses | Phenamil methanesulfonate salt has been used: - to stimulate adipocyte differentiation in 3T3 cells
- to test its effect on lateral flagella expression in Vibrio shilonii
- in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation
| | General Description | Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC). | | Biochem/physiol Actions | Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells. |
| PHENAMIL METHANESULFONATE Preparation Products And Raw materials |
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