GLY-ARG-GLY-ASP-SER-PRO-LYS
GLY-ARG-GLY-ASP-SER-PRO-LYS
  • CAS No.:111119-28-9
Other grades of this product :
GLY-ARG-GLY-ASP-SER-PRO-LYS Basic information
Product Name:GLY-ARG-GLY-ASP-SER-PRO-LYS
Synonyms:H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH;GRGDSPK;GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE;GLY-ARG-GLY-ASP-SER-PRO-LYS;GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE;glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine;EMD 56574;L-Lysine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-
CAS:111119-28-9
MF:C28H49N11O11
MW:715.76
EINECS:
Product Categories:peptide
Mol File:111119-28-9.mol
GLY-ARG-GLY-ASP-SER-PRO-LYS Chemical Properties
density 1.59±0.1 g/cm3(Predicted)
storage temp. -20°C
pka3.60±0.21(Predicted)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
GLY-ARG-GLY-ASP-SER-PRO-LYS Usage And Synthesis
UsesGly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
  • as a blocking peptide to inhibit integrin-fibronectin binding
  • in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
  • for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
  • for the preparation of RGD.Flt23k.NR nanoparticles
  • to determine the involvement of RGD-integrin bonding in cell adhesion process
General DescriptionGly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.
Biochem/physiol ActionsFibronectin analog that binds to integrins.
GLY-ARG-GLY-ASP-SER-PRO-LYS Preparation Products And Raw materials

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