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| Cyclopentanone, 2,5-bis(2-thienylmethylene)- Basic information |
| Cyclopentanone, 2,5-bis(2-thienylmethylene)- Chemical Properties |
| storage temp. | +2C to +8C | | form | Yellow solid |
| Cyclopentanone, 2,5-bis(2-thienylmethylene)- Usage And Synthesis |
| General Description | A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 μM), while exhibiting little activity against PPM1A even at concentrations as high as 100 μM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 μM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 μM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells. |
| Cyclopentanone, 2,5-bis(2-thienylmethylene)- Preparation Products And Raw materials |
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