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| 4-METHOXYPHENYL ISOCYANIDE Basic information |
| 4-METHOXYPHENYL ISOCYANIDE Chemical Properties |
| Melting point | 29-33 °C (lit.) | | Boiling point | 113 °C | | Fp | 224 °F | | storage temp. | -20°C |
| 4-METHOXYPHENYL ISOCYANIDE Usage And Synthesis |
| Uses | 4-Methoxyphenyl isocyanide can be used to synthesize N-(isoquinolin-1-yl)-formamides via reaction with 2-alkynylbenzaldoximes in the presence of silver trifluoromethanesulfonate and bismuth triflate. | | Preparation | To an ice-cooled flask containing a solution of 10.5 gm (0.065 mole) of p-methoxyformanilide in 37.1 gm (0.47 mole) of pyridine and 13.0 ml (0.16 mole) of chloroform is added dropwise at 0°C 6.12 gm (0.040 mole) of phosphorus oxychloride. The solution is stirred for 1? hr at room temperature and then added to 55 ml of ice-water. The water layer is extracted with two 10-ml portions of chloroform; the combined chloroform layer is dried and distilled under reduced pressure, to afford 3.5 gm (40%), b.p. 767C (1.0 mm Hg), IR 2137 c m " 1 (R—NC).
| | Synthesis Reference(s) | Journal of Medicinal Chemistry, 38, p. 2955, 1995 DOI: 10.1021/jm00015a018 |
| 4-METHOXYPHENYL ISOCYANIDE Preparation Products And Raw materials |
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