| (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Basic information |
| Product Name: | (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride |
| Synonyms: | F 2207;IXEL;(1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE;(1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIMETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE;Milnacipran hydrochloride solution;F 2207, Midalcipran, Toledomin, (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride;rel-2α*-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1α*-carboxamide·hydrochloride;rac Milnacipran Hydrochloride |
| CAS: | 101152-94-7 |
| MF: | C15H23ClN2O |
| MW: | 282.81 |
| EINECS: | 620-477-4 |
| Product Categories: | NEGGRAM;Amines;Chiral Reagents;Antibiotic Explorer;Intermediates & Fine Chemicals;Aromatics;Pharmaceuticals |
| Mol File: | 101152-94-7.mol |
| (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Chemical Properties |
| Melting point | 179-1810C |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 19 mg/mL |
| form | solid |
| color | white |
| Merck | 14,6194 |
| CAS DataBase Reference | 101152-94-7(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-39/23/24/25-23/24/25-11 |
| Safety Statements | 7-16-36/37-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GZ1014010 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29242990 |
| Toxicity | LD50 orally in mice: 237 mg/kg (Bonnaud) |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Usage And Synthesis |
| Chemical Properties | Crystalline Solid |
| Uses | Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. |
| Uses | antibacterial |
| General Description | Milnacipran, sold under the brand names Savella?, Ixel?, Dalcipran?, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin. |
| Biological Activity | Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo . |
| Biochem/physiol Actions | Serotonin and norepinephrine reuptake inhibitor (SNRI) |
| (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Preparation Products And Raw materials |
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