2-Amino-5-bromo-3-(hydroxymethyl)pyridine

CAS No.：335031-01-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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2-Amino-5-bromo-3-(hydroxymethyl)pyridine Basic information

Product Name:	2-Amino-5-bromo-3-(hydroxymethyl)pyridine
Synonyms:	(2-AMINO-5-BROMO-3-PYRIDINYL)METHANOL;(2-AMINO-5-BROMO-PYRIDIN-3-YL)-METHANOL;2-Amino-5-bromopyridine-3-methanol;2-Amino-5-bromo-3-(hydroxymethyl)pyridine;2-Amino-5-Bromo-3-(Hydroxymeth;2-Amino-5-bromo-3-pyridinemethanol;2-broMo-4-ethoxypyriMidine;2-AMino-3-hydroxyMethyl-5-broMopyridine
CAS:	335031-01-1
MF:	C6H7BrN2O
MW:	203.04
EINECS:
Product Categories:	Heterocycle-Pyridine series;Aromatics;Hydroxymethyl's;Pyridines;Pyridine;Heterocycles;pharmacetical;Pyridine series;Heterocyclic Compounds
Mol File:	335031-01-1.mol

2-Amino-5-bromo-3-(hydroxymethyl)pyridine Chemical Properties

Melting point	137-140°C
Boiling point	343.5±37.0 °C(Predicted)
density	1.766±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Acetone, Ethyl Acetate, Methanol
pka	13.16±0.10(Predicted)
form	Solid
color	Off-white to yellow
CAS DataBase Reference	335031-01-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933399990

MSDS Information

2-Amino-5-bromo-3-(hydroxymethyl)pyridine Usage And Synthesis

Uses

2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%).

2-Amino-5-bromo-3-(hydroxymethyl)pyridine Preparation Products And Raw materials

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