Exatecan CAS:171335-80-1 is an innovative camptothecin (CPT) analog that demonstrates powerful topoisomerase-I inhibitory and antitumor activities. Its unique structure makes it highly effective against P-glycoprotein (P-gp) mediated multi-drug resistant cells, overcoming a major challenge in cancer therapy. Several Exatecan derivative-based antibody-drug and peptide-drug conjugate payloads exhibit impressive therapeutic indices across a broad spectrum of solid tumors. As a result, Exatecan is paving the way for the development of more effective and targeted cancer treatments, offering new hope for patients battling resistant malignancies.
Payloads and Linker modified Payloads
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