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| Choline tosylate Basic information |
| Product Name: | Choline tosylate | | Synonyms: | [2-HYDROXYETHYL]TRIMETHYLAMMONIUM P-TOLUENESULFONATE SALT;CHOLINE P-TOLUENESULFONATE SALT;CHOLINE TOSYLATE;Choline 4-methylbenzenesulphonate salt;2-Hydroxy-N,N,N-trimethyl-ethanaminium 4-methylbenzenesulfonic acid salt;Choline p-toluenesulfonate;Choline 4-methylbenzenesulphonate salt 99%;(2-Hydroxyethyl)trimethylammonium toluene-4-sulphonate 99% | | CAS: | 55357-38-5 | | MF: | C12H21NO4S | | MW: | 275.36 | | EINECS: | | Product Categories: | Quarternary ammonium salts | | Mol File: | 55357-38-5.mol |
| Choline tosylate Chemical Properties |
| Melting point | 95°C | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Sensitive | Light Sensitive/Hygroscopic | | CAS DataBase Reference | 55357-38-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant/Hygroscopic/Light Sensitive | | HS Code | 2923900090 |
| Choline tosylate Usage And Synthesis |
| Uses | Choline p-Toluenesulfonate Salt is a useful intermediate as well as a choline acetyltransferase (CHAT) substrate. | | Synthesis | A 500 mL reactor was charged at 25 °C with 50 g (268.5 mmol) methyl tosylate and 100 mL acetone to which a solution of 25.1 g (281.6 mmol) N,N-dimethyl ethanolamine in 50.3 g acetone was added continuously at 25 °C over 3 h. The dropping funnel was rinsed with additional acetone. The reaction mixture was stirred at 25 °C for 20 h and the reaction progress was monitored by HPLC. When the level of methyltosylate was lower than 500 ppm the resulting suspension was cooled to 0 °C over 150 min and the suspension was stirred at 0 °C for 60 min. The product was collected by fdtration, washed two times with 175 mL acetone and dried under vacuum at 25 °C to obtain 73.1 g (99 %) of choline tosylate as a white crystalline solid. |
| Choline tosylate Preparation Products And Raw materials |
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