Curcumin
Curcumin
  • CAS No.:458-37-7
Other grades of this product :

Melting point 183 °C
Boiling point 418.73°C (rough estimate)
density 0.93
vapor density 13 (vs air)
refractive index 1.4155-1.4175
Fp 208.9±23.6 °C
storage temp. 2-8°C
solubility ethanol: 10 mg/mL
pka8.09(at 25℃)
form powder
Colour Index 75300
color orange
OdorOdorless
PH RangeYellow (7.8) to red-brown (9.2)
Water Solubility Slightly soluble (hot)
λmax430nm
Merck 14,2673
Concentration1 mCi/ml
BRN 2306965
SolventEthanol
Specific Activity5-15 Ci/mmol
Stability:Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major ApplicationCosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS DataBase Reference458-37-7(CAS DataBase Reference)
EPA Substance Registry SystemCurcumin (458-37-7)

Anaturalphenoliccompound.Potentanti-tumoragenthavinganti-inflammatoryandantioxidantproperties.Inducesapoptosisincancercellsandinhibitsphorbolester-inducedproteinkinaseC(PKC)activity.Reportedtoinhibitproductionofinflammatorycytokinesbyperipheralbloodmonocytesandalveolarmacrophages.PotentinhibitorofEGFRtyrosinekinaseandIBkinase.ChemicalbookInhibitsinduciblenitricoxidesynthase(iNOS),cycloxygenaseandlipoxygenase.Easilypenetratesintothecytoplasmofcells,accumulatinginmembranousstructuressuchasplasmamembrane,endoplasmicreticulumandnuclearenvelope.CurcuminiscurrentlybeingexaminedasapossibletherapeuticforthetreatmentofAlzheimersdisease(Chem.andEng.News90(31),44(2012)).

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