| (2S,4R)-4-METHYLGLUTAMIC ACID Basic information |
| Product Name: | (2S,4R)-4-METHYLGLUTAMIC ACID |
| Synonyms: | SYM 2081;ERYTHRO-4-METHYL-L-GLUTAMIC ACID;(2S,4R)-(+)-2-Amino-4-methylpentanedioic acid;(2S,4R)-4-METHYLGLUTAMIC ACID;(2S,4R)-(+)-2-AMINO-4-METHYLPENTANEDIOIC ACID 99%;(2S-R)-4-METHYLGLUTAMIC ACID;(4R)- 4-Methyl-L-glutamic Acid;erythro-L-4-Methylglutamic Acid |
| CAS: | 31137-74-3 |
| MF: | C6H11NO4 |
| MW: | 161.16 |
| EINECS: | |
| Product Categories: | Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents;Neurochemicals |
| Mol File: | 31137-74-3.mol |
| (2S,4R)-4-METHYLGLUTAMIC ACID Chemical Properties |
| Melting point | 178 °C |
| Boiling point | 287.44°C (rough estimate) |
| density | 1.3482 (rough estimate) |
| refractive index | 1.4230 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: >10 mg/mL |
| form | solid |
| pka | 2.34±0.21(Predicted) |
| color | white |
| CAS DataBase Reference | 31137-74-3(CAS DataBase Reference) |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| (2S,4R)-4-METHYLGLUTAMIC ACID Usage And Synthesis |
| Chemical Properties | White |
| Uses | A highly selective and potent agonist for kainate receptors. |
| Biological Activity | Potent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ . |
| (2S,4R)-4-METHYLGLUTAMIC ACID Preparation Products And Raw materials |
| Raw materials | 2-METHYL-4-OXOPENTANEDIOIC ACID-->(2S,4S)-4-METHYLGLUTAMIC ACID |
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