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| CHLORISONDAMINE DIIODIDE Basic information |
| Product Name: | CHLORISONDAMINE DIIODIDE | | Synonyms: | 4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide;Chlorisondamine (iodide) | | CAS: | 96750-66-2 | | MF: | C14Cl4H20I2N2 | | MW: | 611.94 | | EINECS: | | Product Categories: | | Mol File: | 96750-66-2.mol |
| CHLORISONDAMINE DIIODIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: ~3.75 mg/mL | | form | solid | | color | white |
| Hazard Codes | Xn,N | | Risk Statements | 22-50 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 2 |
| CHLORISONDAMINE DIIODIDE Usage And Synthesis |
| Description | Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg. | | Uses | Chlorisondamine diiodide has been used:- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
| | Biochem/physiol Actions | Chlorisondamine diiodide mediates ganglionic and central blockade. |
| CHLORISONDAMINE DIIODIDE Preparation Products And Raw materials |
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